Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

Abstract Background p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling. p130Cas has been shown to be highly expressed in a vari...

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Bibliographic Details
Main Authors: Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti, Sara Cabodi
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Adaptor proteins
Mouse primary keratinocytes
Cell adhesion
Cell signaling and cell differentiation
Online Access:http://link.springer.com/article/10.1186/s12964-018-0289-z

Internet

http://link.springer.com/article/10.1186/s12964-018-0289-z

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