Deletion of the forebrain mineralocorticoid receptor impairs social discrimination and decision-making in male, but not in female mice

Deletion of the forebrain mineralocorticoid receptor impairs social discrimination and decision-making in male, but not in female mice

Social interaction with unknown individuals requires fast processing of information to decide whether it is friend or foe. This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptors (MR) and glucocorticoid receptors...

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Bibliographic Details
Main Authors: Judith P Ter Horst, Maaike evan der Mark, Jiska eKentrop, Marit eArp, Rixt evan der Veen, Ronald eDe Kloet, Melly S Oitzl
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Discrimination
knockout mice
Sex
mineralocorticoid receptor
social approach
social discrimination
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00026/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00026/full

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