Hydroxy-Propil-β-Cyclodextrin Inclusion Complexes of two Biphenylnicotinamide Derivatives: Formulation and Anti-Proliferative Activity Evaluation in Pancreatic Cancer Cell Models

Hydroxy-Propil-β-Cyclodextrin Inclusion Complexes of two Biphenylnicotinamide Derivatives: Formulation and Anti-Proliferative Activity Evaluation in Pancreatic Cancer Cell Models

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with poor outcomes largely due to its unique microenvironment, which is responsible for the low response to drugs and drug-resistance phenomena. This clinical need led us to explore new therapeutic approaches for sys...

Full description

Bibliographic Details
Main Authors: Rosa Maria Iacobazzi, Annalisa Cutrignelli, Angela Stefanachi, Letizia Porcelli, Angela Assunta Lopedota, Roberta Di Fonte, Antonio Lopalco, Simona Serratì, Valentino Laquintana, Nicola Silvestris, Massimo Franco, Saverio Cellamare, Francesco Leonetti, Amalia Azzariti, Nunzio Denora
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic ductal adenocarcinoma
cyclodextrin inclusion complex
phase solubility studies
preformulation studies
biphenylnicotinamide derivatives
Online Access:https://www.mdpi.com/1422-0067/21/18/6545

Internet

https://www.mdpi.com/1422-0067/21/18/6545

Similar Items