Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro

Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro

Tick saliva is a rich source of pharmacologically and immunologically active molecules. These salivary components are indispensable for successful blood feeding on vertebrate hosts and are believed to facilitate the transmission of tick-borne pathogens. Here we present the functional and structural...

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Bibliographic Details
Main Authors: Adéla Chlastáková, Jan Kotál, Zuzana Beránková, Barbora Kaščáková, Larissa Almeida Martins, Helena Langhansová, Tatyana Prudnikova, Monika Ederová, Ivana Kutá Smatanová, Michail Kotsyfakis, Jindřich Chmelař
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
tick
serpin
X-ray crystallography
blood coagulation
inflammation
adaptive immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.626200/full

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