The Use of Tick Salivary Proteins as Novel Therapeutics

by Jindřich Chmelař, Jan Kotál, Jan Kotál, Anna Kovaříková, Michail Kotsyfakis, Michail Kotsyfakis
Published 2019-06-01

The health impact of Saharan dust exposure

by Michail Kotsyfakis, Sotirios G. Zarogiannis, Evridiki Patelarou
Published 2019-11-01

Tick Salivary Compounds for Targeted Immunomodulatory Therapy

by Hajer Aounallah, Hajer Aounallah, Chaima Bensaoud, Youmna M’ghirbi, Fernanda Faria, Jindr̆ich Chmelar̆, Michail Kotsyfakis, Michail Kotsyfakis
Published 2020-09-01

Long Non-Coding RNAs and Their Potential Roles in the Vector–Host–Pathogen Triad

by Parwez Ahmad, Chaima Bensaoud, Imen Mekki, Mujeeb Ur Rehman, Michail Kotsyfakis
Published 2021-01-01

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

by Jindřich Chmelař, Jan Kotál, Jan Kotál, Helena Langhansová, Helena Langhansová, Michail Kotsyfakis
Published 2017-05-01

Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro

by Adéla Chlastáková, Jan Kotál, Jan Kotál, Zuzana Beránková, Barbora Kaščáková, Larissa Almeida Martins, Helena Langhansová, Tatyana Prudnikova, Monika Ederová, Ivana Kutá Smatanová, Michail Kotsyfakis, Michail Kotsyfakis, Jindřich Chmelař
Published 2021-03-01

Comparison of the hemolysis machinery in two evolutionarily distant blood-feeding arthropod vectors of human diseases.

by Moataza Dorrah, Chaima Bensaoud, Amr A Mohamed, Daniel Sojka, Taha T M Bassal, Michail Kotsyfakis
Published 2021-02-01

Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses.

by Hitoshi Tsujimoto, Michail Kotsyfakis, Ivo M B Francischetti, Jai Hoon Eum, Michael R Strand, Donald E Champagne
Published 2012-01-01

Mialostatin, a Novel Midgut Cystatin from <i>Ixodes ricinus</i> Ticks: Crystal Structure and Regulation of Host Blood Digestion

by Jan Kotál, Michal Buša, Veronika Urbanová, Pavlína Řezáčová, Jindřich Chmelař, Helena Langhansová, Daniel Sojka, Michael Mareš, Michail Kotsyfakis
Published 2021-05-01

Antiplasmodial activity is an ancient and conserved feature of tick defensins

by Alejandro Cabezas-Cruz, Miray Tonk, Anne Bouchut, Christine Pierrot, Raymond John Pierce, Michail Kotsyfakis, Mohammad Rahnamaeian, Andreas Vilcinskas, Jamal Khalife, James Jason Valdes
Published 2016-10-01

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus micropl...

by Teresa C Assumpção, Dongying Ma, Daniella M Mizurini, R Manjunatha Kini, José M C Ribeiro, Michail Kotsyfakis, Robson Q Monteiro, Ivo M B Francischetti
Published 2016-01-01

Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties

by Jinwei Chai, Xin Chen, Tiaofei Ye, Baishuang Zeng, Qingye Zeng, Jiena Wu, Barbora Kascakova, Larissa Almeida Martins, Tatyana Prudnikova, Ivana Kuta Smatanova, Michail Kotsyfakis, Xueqing Xu
Published 2021-04-01

<i>Ixodes ricinus</i> Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement

by Jan Kotál, Stéphanie G. I. Polderdijk, Helena Langhansová, Monika Ederová, Larissa A. Martins, Zuzana Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A. Huntington, Jindřich Chmelař
Published 2021-08-01

The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

by Xiaowei Wang, Dana K Shaw, Holly L Hammond, Fayyaz S Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J Perkins, Joseph V Bonventre, Thangam S Velayutham, Sean M Evans, Kyle G Rodino, Lauren VieBrock, Karen M Scanlon, Nicholas H Carbonetti, Jason A Carlyon, Edward A Miao, Jere W McBride, Michail Kotsyfakis, Joao H F Pedra
Published 2016-08-01

Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

by Adela S. Oliva Chávez, Xiaowei Wang, Liron Marnin, Nathan K. Archer, Holly L. Hammond, Erin E. McClure Carroll, Dana K. Shaw, Brenden G. Tully, Amanda D. Buskirk, Shelby L. Ford, L. Rainer Butler, Preeti Shahi, Kateryna Morozova, Cristina C. Clement, Lauren Lawres, Anya J. O’ Neal, Choukri Ben Mamoun, Kathleen L. Mason, Brandi E. Hobbs, Glen A. Scoles, Eileen M. Barry, Daniel E. Sonenshine, Utpal Pal, Jesus G. Valenzuela, Marcelo B. Sztein, Marcela F. Pasetti, Michael L. Levin, Michail Kotsyfakis, Steven M. Jay, Jason F. Huntley, Lloyd S. Miller, Laura Santambrogio, Joao H. F. Pedra
Published 2021-06-01