Novel 2-mercapto imidazole and triazole derivatives as potent TGR5 receptor agonists
TGR5 is a bile acid G protein-coupled receptor (GPCR), which is an attractive therapeutic target for the treatment of obesity, and its highly associated Type 2 diabetes. Activation of TGR5 promotes secretion of glucagon like peptide-1 (GLP-1) and activates insulin secretion. Series of novel 2-mercap...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-03-01
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| Series: | Medicine in Drug Discovery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590098619300028 |