Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks

Networks of protein-protein interactions (PPIs) link all aspects of cellular biology. Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease, and as such, there is growing interest in the discovery of small molecules that either promote or inhibit PPIs. Protein-protei...

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Bibliographic Details
Main Authors: Laura C Cesa, Anna K Mapp, Jason E Gestwicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00119/full