Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer

Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer

Abstract Amphibian venom-derived peptides have high potential in the field of anticancer drug discovery. We have isolated a novel Bowman-Birk proteinase inhibitor (BBI)-type peptide from the skin secretion of Pelophylax esculentus (PE) named PE-BBI, and evaluated its bio-functions and anti-cancer ac...

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Bibliographic Details
Main Authors: Peng Lyu, Lilin Ge, Rui Ma, Ran Wei, Cian M. McCrudden, Tianbao Chen, Chris Shaw, Hang Fai Kwok
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Pelophylax Esculentus
Bowman-Birk Protease Inhibitor (BBI)
Skin Secretions
Anti-cancer Ability
Synthetic Replicates
Online Access:https://doi.org/10.1038/s41598-018-32947-5

Internet

https://doi.org/10.1038/s41598-018-32947-5

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