An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.
Bibliographic Details
| Main Authors: |
Shensi Shen,
Sara Faouzi,
Amandine Bastide,
Sylvain Martineau,
Hélène Malka-Mahieu,
Yu Fu,
Xiaoxiao Sun,
Christine Mateus,
Emilie Routier,
Severine Roy,
Laurent Desaubry,
Fabrice André,
Alexander Eggermont,
Alexandre David,
Jean-Yves Scoazec,
Stéphan Vagner,
Caroline Robert |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2019-12-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-019-13360-6
|
|---|
