The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.

The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.

The secreted, goblet cell-derived protein Clca1 (chloride channel regulator, calcium-activated-1) has been linked to diseases with mucus overproduction, including asthma and cystic fibrosis. In the intestine Clca1 is found in the mucus with an abundance and expression pattern similar to Muc2, the ma...

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Bibliographic Details
Main Authors: Nancy A Erickson, Elisabeth E L Nyström, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M Heimesaat, André Fischer, Stefan Bereswill, George M H Birchenough, Achim D Gruber, Malin E V Johansson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4498832?pdf=render

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http://europepmc.org/articles/PMC4498832?pdf=render

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