Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Reactive oxygen species induced by endoplasmic reitculum stress can be exploited for cancer therapy. Here, nanoparticles are targetted to the endoplasmic reticulum and, when accompanied by PDT, produce stress resulting in calreticulin exposure on the cell surface, which activates dendritic cells.

Bibliographic Details
Main Authors: Wei Li, Jie Yang, Lihua Luo, Mengshi Jiang, Bing Qin, Hang Yin, Chunqi Zhu, Xiaoling Yuan, Junlei Zhang, Zhenyu Luo, Yongzhong Du, Qingpo Li, Yan Lou, Yunqing Qiu, Jian You
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11269-8

Internet

https://doi.org/10.1038/s41467-019-11269-8

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