Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.

Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.

BACKGROUND:Pregnane X receptor (PXR) regulates the expression of drug-metabolizing enzymes and transport enzymes. NF-κB not only plays a role in liver homeostasis and injury-healing processes by regulating inflammatory responses but may also regulate the transcription of PXR. Currently, genetic poly...

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Main Authors: Jingwei Zhang, Zhenzhen Zhao, Hao Bai, Minjin Wang, Lin Jiao, Wu Peng, Tao Wu, Tangyuheng Liu, Hao Chen, Xingbo Song, Lijuan Wu, Xuejiao Hu, Qian Wu, Juan Zhou, Jiajia Song, Mengyuan Lyv, Binwu Ying
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222033

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https://doi.org/10.1371/journal.pone.0222033

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