Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.

Bibliographic Details
Main Authors: Pooja Munnilal Tiwari, Daryll Vanover, Kevin E. Lindsay, Swapnil Subhash Bawage, Jonathan L. Kirschman, Sushma Bhosle, Aaron W. Lifland, Chiara Zurla, Philip J. Santangelo
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06508-3

Internet

https://doi.org/10.1038/s41467-018-06508-3

Similar Items