The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines...

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Bibliographic Details
Main Authors: Rafat M. Mohareb, Abeer A. Mohamed
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/15/5/3602/