CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1

CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1

Porcine alveolar macrophages without the CD163 SRCR5 domain are resistant to porcine reproductive and respiratory syndrome virus (PRRSV) infection. However, whether the deletion of CD163 SRCR5 in MARC-145 cells confers resistance to PRRSV and interaction of which of the host proteins with CD163 is i...

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Bibliographic Details
Main Authors: Piao Yu, Ruiping Wei, Wenjuan Dong, Zhenbang Zhu, Xiaoxiao Zhang, Yaosheng Chen, Xiaohong Liu, Chunhe Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
PRRSV
CD163
SRCR5
calpain 1
resistance
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03115/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.03115/full

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