Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

Abstract Background Compounds in clinical development for nonalcoholic steatohepatitis (NASH) improve liver histopathology in diet-induced obese mouse models of biopsy-confirmed NASH. Since the biopsy section used for histopathological evaluation represents only < 1% of the whole mouse liver, we...

Full description

Bibliographic Details
Main Authors: Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Christina Christoffersen, Michael Feigh, Niels Vrang, Jonathan David Roth, Mary Erickson, Luciano Adorini, Jacob Jelsing
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Gastroenterology
Subjects:
Nonalcoholic steatohepatitis
Stereology
Liver morphometry
Pharmacodynamics
Disease model
Liver biopsy
Online Access:https://doi.org/10.1186/s12876-019-1149-z

Internet

https://doi.org/10.1186/s12876-019-1149-z

Similar Items