Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors

Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors

Nosocomial pathogens that develop multidrug resistance present an increasing problem for healthcare facilities. Due to its rapid rise in antibiotic resistance, Acinetobacter baumannii is one of the most concerning gram-negative species. A. baumannii typically infects immune compromised individuals r...

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Bibliographic Details
Main Authors: Ursula Waack, Tanya L. Johnson, Khalil Chedid, Chuanwu Xi, Lyle A. Simmons, Harry L. T. Mobley, Maria Sandkvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Acinetobacter baumannii
type II secretion
high-throughput screening
small molecule inhibitors
LipA
lipase activity
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00380/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00380/full

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