Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.

Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.

Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a conduit for the viral genome to enter the cyto...

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Bibliographic Details
Main Authors: Charles J Shoemaker, Kathryn L Schornberg, Sue E Delos, Corinne Scully, Hassan Pajouhesh, Gene G Olinger, Lisa M Johansen, Judith M White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3575416?pdf=render

Internet

http://europepmc.org/articles/PMC3575416?pdf=render

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