Prediction of CRISPR/Cas9 single guide RNA cleavage efficiency and specificity by attention-based convolutional neural networks

Prediction of CRISPR/Cas9 single guide RNA cleavage efficiency and specificity by attention-based convolutional neural networks

CRISPR/Cas9 is a preferred genome editing tool and has been widely adapted to ranges of disciplines, from molecular biology to gene therapy. A key prerequisite for the success of CRISPR/Cas9 is its capacity to distinguish between single guide RNAs (sgRNAs) on target and homologous off-target sites....

Full description

Bibliographic Details
Main Authors: Guishan Zhang, Tian Zeng, Zhiming Dai, Xianhua Dai
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
CRISPR/Cas9
sgRNA
On-target
Off-target
Deep learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021000738

Internet

http://www.sciencedirect.com/science/article/pii/S2001037021000738

Similar Items