Higenamine Attenuates Neuropathic Pain by Inhibition of NOX2/ROS/TRP/P38 Mitogen-Activated Protein Kinase/NF-ĸB Signaling Pathway

Higenamine Attenuates Neuropathic Pain by Inhibition of NOX2/ROS/TRP/P38 Mitogen-Activated Protein Kinase/NF-ĸB Signaling Pathway

Oxidative stress damage is known as one of the important factors that induce neuropathic pain (NP). Using antioxidant therapy usually achieves an obvious curative effect and alleviates NP. Previous pharmacological studies have shown that higenamine (Hig) performs to be antioxidant and anti-inflammat...

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Bibliographic Details
Main Authors: Bing Yang, Shengsuo Ma, Chunlan Zhang, Jianxin Sun, Di Zhang, Shiquan Chang, Yi Lin, Guoping Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
higenamine
neuropathic pain
oxidative stress
neuroinflammation
transient receptor potential
NOX2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.716684/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.716684/full

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