Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway

Helicobacter pylori is associated with hypergastrinemia, which has been linked to the development of gastric diseases. Although the molecular mechanism is not fully understood, H. pylori is known to modulate the Erk pathway for induction of gastrin expression. Herein we found that an epidermal growt...

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Bibliographic Details
Main Authors: Niluka Gunawardhana, Sungil Jang, Yun Hui Choi, Youngmin A. Hong, Yeong-Eui Jeon, Aeryun Kim, Hanfu Su, Ji-Hye Kim, Yun-Jung Yoo, D. Scott Merrell, Jinmoon Kim, Jeong-Heon Cha
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Helicobacter pylori
gastrin
gastric cancer
HB-EGF
Erk
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00541/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00541/full

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