Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

In the present study we aimed to identify novel mechanisms and therapeutics for thoracic aortic aneurysm (TAA) in Fbn1C1039G/+ Marfan Syndrome (MFS) mice. The expression of mature/active TGFβ and its downstream effector NOX4 were upregulated while tetrahydrobiopterin (H4B) salvage enzyme dihydrofola...

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Bibliographic Details
Main Authors: Kai Huang, Yongchen Wang, Kin Lung Siu, Yixuan Zhang, Hua Cai
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
NADPH oxidase (NOX)
NOX isoform 4 (NOX4)
Reactive oxygen species (ROS)
eNOS uncoupling/recoupling
Thoracic aortic aneurysm (TAA)
Marfan syndrome (MFS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309629

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http://www.sciencedirect.com/science/article/pii/S2213231720309629

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