Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

Anti-CRISPR proteins offer the means of regulating CRISPR-Cas9 activity. Here the authors present the structure and biochemical characterisation of AcrIIC2 Nme alone and in complex with Cas9.

Bibliographic Details
Main Authors: Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima Hidalgo-Reyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10577-3

Internet

https://doi.org/10.1038/s41467-019-10577-3

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