Dickkopf-3 contributes to the regulation of anti-tumor immune responses by mesenchymal stem cells.

Dickkopf-3 contributes to the regulation of anti-tumor immune responses by mesenchymal stem cells.

Mesenchymal stem cells (MSCs) are known to limit immune responses in vivo by multiple soluble factors. Dickkopf-3 (DKK3), a secreted glycoprotein, has recently been identified as a novel immune modulator. Since DKK3 has been reported to be produced by MSCs we investigated whether DKK3 contributes to...

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Bibliographic Details
Main Authors: Kun-Hui eLu, Amel eTounsi, Naveen eShridhar, Günter eKüblbeck, Alexandra eKlevenz, Sandra eProkosch, Tobias eBald, Thomas eTüting, Bernd eArnold
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Immunology
Subjects:
Melanoma
T cell
mesenchymal stem cell
tumor stroma
anti-tumor response
Dickkopf-3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00645/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00645/full

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