Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime

Abstract Background Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed using either a gene deletion or a gene silencing approaches, have shown thi...

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Bibliographic Details
Main Authors: Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser, R. Daniel Bonfil, Rafael Fridman, Hans Richter, Juergen Funk, Marcus J. Moeller, Christos Chatziantoniou, Marco Prunotto
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Translational Medicine
Subjects:
Fibrosis
DDR1 inhibition
Glomerulosclerosis
CKD
Online Access:http://link.springer.com/article/10.1186/s12967-018-1524-5

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http://link.springer.com/article/10.1186/s12967-018-1524-5

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