Large Volume Direct Injection Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry-Based Comparative Pharmacokinetic Study between Single and Combinatory Uses of <i>Carthamus tinctorius</i> Extract and Notoginseng Total Saponins

Large Volume Direct Injection Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry-Based Comparative Pharmacokinetic Study between Single and Combinatory Uses of <i>Carthamus tinctorius</i> Extract and Notoginseng Total Saponins

The combination of <i>Carthamus tinctorius</i> extract (CTE) and notoginseng total saponins (NGTS), namely, CNP, presents a synergistic effect on myocardial ischemia protection. Herein, comparative pharmacokinetic studies between CNP and CTE/NGTS were conducted to clarify their synergist...

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Bibliographic Details
Main Authors: Jinfeng Chen, Xiaoyu Guo, Yingyuan Lu, Mengling Shi, Haidong Mu, Yi Qian, Jinlong Wang, Mengqiu Lu, Mingbo Zhao, Pengfei Tu, Yuelin Song, Yong Jiang
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
<i>carthamus tinctorius</i> extract
notoginseng total saponins
comparative pharmacokinetic study
large volume direct injection
compatibility mechanism
Online Access:https://www.mdpi.com/1999-4923/12/2/180

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https://www.mdpi.com/1999-4923/12/2/180

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