A Review of the Inhibition of the Mitochondrial ATP Synthase by IF1 in vivo: Reprogramming Energy Metabolism and Inducing Mitohormesis

A Review of the Inhibition of the Mitochondrial ATP Synthase by IF1 in vivo: Reprogramming Energy Metabolism and Inducing Mitohormesis

The ATPase Inhibitory Factor 1 (IF1) is the physiological inhibitor of the mitochondrial ATP synthase. Herein, we summarize the regulation of the expression and activity of IF1 as a main driver of the activity of oxidative phosphorylation (OXPHOS) in mammalian tissues. We emphasize that the expressi...

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Bibliographic Details
Main Authors: Ana García-Aguilar, José M. Cuezva
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
ATP synthase
ATPase inhibitory factor 1
energy metabolism
metabolic preconditioning
mitohormesis
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01322/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01322/full

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