Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

Abstract Background The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a central role in microglia activation in r...

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Bibliographic Details
Main Authors: Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
ApoE4
Microglial activation
sTREM2
Cognitive decline
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-020-00407-2

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http://link.springer.com/article/10.1186/s13024-020-00407-2

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