EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination

EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination

Abstract Background The G protein-coupled receptor EBI2 (Epstein-Barr virus-induced gene 2) is activated by 7α, 25-dihydroxycholesterol (7α25HC) and plays a role in T cell-dependant antibody response and B cell migration. Abnormal EBI2 signaling is implicated in a range of autoimmune disorders; howe...

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Bibliographic Details
Main Authors: Aleksandra Rutkowska, Andreas W. Sailer, Kumlesh K. Dev
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
Epstein-Barr virus-induced gene 2 (EBI2 receptor)
Multiple sclerosis
Myelination
Demyelination
Organotypic slices
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-017-1025-0

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http://link.springer.com/article/10.1186/s12974-017-1025-0

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