Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response

Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response

Dendritic cells (DCs) transfected with total amplified tumor cell RNA have the potential to induce broad antitumor immune responses. However, analytical methods required for quantitatively assessing the integrity, fidelity, and functionality of the amplified RNA are lacking. We have developed a seri...

Full description

Bibliographic Details
Main Authors: Jacoba G Slagter-Jäger, Alexa Raney, Whitney E Lewis, Mark A DeBenedette, Charles A Nicolette, Irina Y Tcherepanova
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
dendritic cell
PCR
RNA
RNA amplification
RNA cap
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301500

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301500

Similar Items