Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.

Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.

OBJECTIVES:This purpose of this study was to examine clinical-pathologic factors--particularly smoking and brain metastases--in EGFR mutation positive (M(+)) lung adenocarcinoma (ADC) to determine their impact on survival in patients treated with first line EGFR TKI. METHODS:A retrospective review o...

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Bibliographic Details
Main Authors: Amit Jain, Cindy Lim, Eugene MingJin Gan, David Zhihao Ng, Quan Sing Ng, Mei Kim Ang, Angela Takano, Kian Sing Chan, Wu Meng Tan, Ravindran Kanesvaran, Chee Keong Toh, Chian Min Loo, Anne Ann Ling Hsu, Anantham Devanand, Chong Hee Lim, Heng Nung Koong, Tina Koh, Kam Weng Fong, Swee Peng Yap, Su Woon Kim, Balram Chowbay, Lynette Oon, Kiat Hon Lim, Wan Teck Lim, Eng Huat Tan, Daniel Shao Weng Tan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4425557?pdf=render

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http://europepmc.org/articles/PMC4425557?pdf=render

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