Changes in relative histone abundance and heterochromatin in αA-crystallin and αB-crystallin knock-in mutant mouse lenses

Changes in relative histone abundance and heterochromatin in αA-crystallin and αB-crystallin knock-in mutant mouse lenses

Abstract Objective Understanding the mechanisms of cataract formation is important for age-related and hereditary cataracts caused by mutations in lens protein genes. Lens proteins of the crystallin gene families α-, β-, and γ-crystallin are the most abundant proteins in the lens. Single point mutat...

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Bibliographic Details
Main Authors: Usha P. Andley, Brittney N. Naumann, Paul D. Hamilton, Stephanie L. Bozeman
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Research Notes
Subjects:
Crystallin
Cataract
Mouse lens
Histones
Mass spec
Electron microscopy
Online Access:http://link.springer.com/article/10.1186/s13104-020-05154-7

Internet

http://link.springer.com/article/10.1186/s13104-020-05154-7

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