Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Nav1.1 VGSC α-subunit, underlie several forms of epilepsy, including Dravet syndrome (DS) and genetic epilepsy w...

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Bibliographic Details
Main Authors: Stacey B. Dutton, Christopher D. Makinson, Ligia A. Papale, Anupama Shankar, Bindu Balakrishnan, Kazu Nakazawa, Andrew Escayg
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
SCN1A
Ion channels
Interneurons
Pyramidal neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002999

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http://www.sciencedirect.com/science/article/pii/S0969996112002999

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