Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

Abstract Background Angelman Syndrome (AS) is a rare genetic disorder characterized by impaired communication, motor and balance deficits, intellectual disabilities, recurring seizures and abnormal sleep patterns. The genetic cause of AS is neuronal-specific loss of expression of UBE3A (ubiquitin-pr...

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Bibliographic Details
Main Authors: N. A. Copping, J. L. Silverman
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Autism
Subjects:
Genetics
Mouse models
Seizures
Sleep
Behavior
Angelman Syndrome
Online Access:https://doi.org/10.1186/s13229-021-00416-y

Internet

https://doi.org/10.1186/s13229-021-00416-y

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