Impact of Polyallylamine Hydrochloride on Gene Expression and Karyotypic Stability of Multidrug Resistant Transformed Cells

Impact of Polyallylamine Hydrochloride on Gene Expression and Karyotypic Stability of Multidrug Resistant Transformed Cells

The synthetic polymer, polyallylamine hydrochloride (PAA), is found in a variety of applications in biotechnology and medicine. It is used in gene and siRNA transfer, to form microcapsules for targeted drug delivery to damaged and tumor cells. Conventional chemotherapy often does not kill all cancer...

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Bibliographic Details
Main Authors: Larisa Alekseenko, Mariia Shilina, Irina Kozhukharova, Olga Lyublinskaya, Irina Fridlyanskaya, Nikolay Nikolsky, Tatiana Grinchuk
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
polyallylamine hydrochloride
Chinese hamster cells V-79
multidrug resistance
<i>p53</i>
<i>c-fos</i>
<i>topo2-α</i>
Online Access:https://www.mdpi.com/2073-4409/9/10/2332

Internet

https://www.mdpi.com/2073-4409/9/10/2332

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