In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution

In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution

The role of clonal complexity has gradually been accepted in infection by Mycobacterium tuberculosis (MTB), although analyses of this issue are limited. We performed an in-depth study of a case of recurrent MTB infection by integrating genotyping, whole genome sequencing, analysis of gene expression...

Full description

Bibliographic Details
Main Authors: Darío García de Viedma, Yurena Navarro, Laura Pérez-Lago, Marta Herranz, Olalla Sierra, Iñaki Comas, Javier Sicilia, Emilio Bouza
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Microbiology
Subjects:
microevolution
Mycobacterium tuberculosis
functional analysis
in vitro infections
in vivo infections
whole genome sequencing
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00694/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00694/full

Similar Items