Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea Receptor

Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea Receptor

Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels in pancreatic β-cells play a crucial role in insulin secretion and glucose homeostasis. These channels are composed of two subunits: a pore-forming subunit (Kir6.2) and a regulatory subunit (sulphonylurea receptor-1). Recent studies id...

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Bibliographic Details
Main Author: Peter Proks
Format: Article
Language:English
Published: Korean Diabetes Association 2013-06-01
Series:Diabetes & Metabolism Journal
Subjects:
ABC transporter
Insulin secretion
K channels
Kir6.2
Neonatal diabetes
Pancreatic β-cell
Sulphonylurea receptor
Sulphonylureas
Online Access:http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-157.pdf

Internet

http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-157.pdf

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