Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter

Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter

The human norepinephrine transporter (hNET) is a member of the neurotransmitter/sodium symporter family, which also includes the neuronal monoamine transporters for serotonin (SERT) and dopamine (DAT). Its involvement in chronic pain and many neurological disorders underlies its pharmaceutical impor...

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Bibliographic Details
Main Authors: Prerna Jha, Lotten Ragnarsson, Richard J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
monoamine transporter
docking guided mutagenesis
noradrenaline uptake
molecular modeling
structural determinants
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00217/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00217/full

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