Kinetics of Phenotypic and Functional Changes in Mouse Models of Sponge Implants: Rational Selection to Optimize Protocols for Specific Biomolecules Screening Purposes

Kinetics of Phenotypic and Functional Changes in Mouse Models of Sponge Implants: Rational Selection to Optimize Protocols for Specific Biomolecules Screening Purposes

The sponge implant has been applied as an important in vivo model for the study of inflammatory processes as it induces the migration, proliferation, and accumulation of inflammatory cells, angiogenesis, and extracellular matrix deposition in its trabeculae. The characterization of immune events in...

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Main Authors: Mariana Ferreira Lanna, Lucilene Aparecida Resende, Rodrigo Dian de Oliveira Aguiar-Soares, Marina Barcelos de Miranda, Ludmila Zanandreis de Mendonça, Otoni Alves de Oliveira Melo Júnior, Reysla Maria da Silveira Mariano, Jaqueline Costa Leite, Patricia Silveira, Rodrigo Corrêa-Oliveira, Walderez Ornelas Dutra, Alexandre Barbosa Reis, Olindo Assis Martins-Filho, Sandra Aparecida Lima de Moura, Denise Silveira-Lemos, Rodolfo Cordeiro Giunchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
sponge implant model
biomolecules screening
dynamics of phenotypic and functional features
immunophenotyping
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.538203/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2020.538203/full

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