Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration

Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration

Acute skeletal muscle injury triggers an expansion of fibro/adipogenic progenitors (FAPs) and a transient stage of fibrogenesis characterized by extracellular matrix deposition. While the perpetuation of such phase can lead to permanent tissue scarring, the consequences of its suppression remain to...

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Bibliographic Details
Main Authors: Daniela Fiore, Robert N. Judson, Marcela Low, Sunny Lee, Erica Zhang, Claudia Hopkins, Peter Xu, Andrea Lenzi, Fabio M.V. Rossi, Dario R. Lemos
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Stem Cell Research
Subjects:
Fibro/adipogenic progenitors
Satellite cells
Fibrosis
Myogenesis
Regeneration
Protein-tyrosine kinase inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116300708

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http://www.sciencedirect.com/science/article/pii/S1873506116300708

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