Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice

Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice

One of the proposed strategies for the development of a more efficient HIV-1 vaccine is based on the identification of proteins binding to a paratope of chosen broadly neutralizing antibody (bNAb) that will mimic cognate HIV-1 Env (glyco)protein epitope and could be used as potent immunogens for ind...

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Bibliographic Details
Main Authors: Milan Kuchař, Petr Kosztyu, Veronika Daniel Lišková, Jiří Černý, Hana Petroková, Eliška Vróblová, Michal Malý, Lucie Vaňková, Michal Křupka, Leona Rašková Kafková, Pavlína Turánek Knotigová, Jarmila Dušková, Jan Dohnálek, Josef Mašek, Jaroslav Turánek, Milan Raška, Petr Malý
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Virulence
Subjects:
protein scaffold
protein mimetics
combinatorial library
env glycoprotein
broadly neutralizing antibody
hiv vaccine
Online Access:http://dx.doi.org/10.1080/21505594.2021.1920251

Internet

http://dx.doi.org/10.1080/21505594.2021.1920251

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