M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

Huntington’s disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology is most prominent in the striatum, the central hub of the basal ganglia. The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mappe...

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Bibliographic Details
Main Authors: Sara Fernández-García, Sara Conde-Berriozabal, Esther García-García, Clara Gort-Paniello, David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Soria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch, Mercè Masana
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
optogenetics
long-term depression
basal ganglia
cortico-striatal
motor behaviour
striatum
Online Access:https://elifesciences.org/articles/57017

Internet

https://elifesciences.org/articles/57017

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