Can radiosensitivity associated with defects in DNA repair be overcome by mitochondrial-targeted antioxidant radioprotectors

Can radiosensitivity associated with defects in DNA repair be overcome by mitochondrial-targeted antioxidant radioprotectors

Radiation oncologists have observed variation in normal tissue responses between patients in many instances with no apparent explanation. The association of clinical tissue radiosensitivity with specific genetic repair defects (Wegner’s Syndrome, Ataxia Telangiectasia, Bloom’s Syndrome, and Fanconi...

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Bibliographic Details
Main Authors: Joel S Greenberger, Hebist eBerhane, Ashwin eShinde, Byung Han Rhieu, Mark eBernard, Peter eWipf, Erin M. Skoda, Michael Wayne Epperly
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Oncology
Subjects:
Fanconi Anemia
Mitochondria
Radioprotectors
GS-Nitroxide
Clinical Radiosensitivity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00024/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00024/full

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