Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State

Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State

The antinociceptive effect of methadone in the morphine-resistant inflammatory pain state was described in the paw-withdrawal test using the complete Freund’s adjuvant (CFA)-induced mouse inflammatory pain model. After intraplantar (i.pl.) injection of CFA, thermal hyperalgesia was observed in the i...

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Bibliographic Details
Main Authors: Chizuko Watanabe, Asami Komiyama, Masaru Yoshizumi, Shinobu Sakurada, Hirokazu Mizoguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
antinociception
methadone
morphine
inflammatory pain
restore
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.593647/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.593647/full

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