Systemic AArh10 provides higher transgene expression than AAV9, in the brain and the spinal cord of neonatal mice

Systemic AArh10 provides higher transgene expression than AAV9, in the brain and the spinal cord of neonatal mice

Systemic delivery of self-complementary (sc) adeno-associated-virus vector of serotype 9 (AAV9) was recently shown to provide robust and widespread gene transfer to the central nervous system (CNS), opening new avenues for practical and non-invasive gene therapy of neurological diseases. More recent...

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Bibliographic Details
Main Authors: Yannick eTanguy, Maria Grazia eBiferi, Aurore eBesse, Stéphanie eAstord, Mathilde eCohen-Tannoudji, Thibaut eMarais, Martine eBarkats
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Central Nervous System
Gene Therapy
Peripheral Nervous System
motor neuron
adeno-associated virus
SMA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00036/full

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http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00036/full

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