Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

Analyzing host cells' transcriptional response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying viral pathogenesis. First, analysis of expression profiles of lung cell lines A549 and Calu3 revealed upregulation of anti...

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Bibliographic Details
Main Authors: Komudi Singh, Yun-Ching Chen, Shahin Hassanzadeh, Kim Han, Jennifer T. Judy, Fayaz Seifuddin, Ilker Tunc, Michael N. Sack, Mehdi Pirooznia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
COVID-19
SARS-CoV-2
transcriptomics
co-expression network analysis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.599261/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.599261/full

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