Analysis of the Th1/Th2 Paradigm in Transplantation: Interferon-γ Deficiency Converts Th1-Type Proislet Allograft Rejection to a Th2-Type Xenograft-Like Response
The rejection mechanisms for fetal proislet allografts and pig proislet xenografts in mice are characterized by different intragraft cytokine mRNA profiles and cellular responses. Allograft rejection is predominantly CD8 T-cell-dependent and is associated with a Th1-type cytokine pattern (i.e., IFN-...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
1999-07-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/096368979900800404 |