Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity

Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity

Filamentous temperature-sensitive Z (FtsZ) is a prokaryotic protein with an essential role in the bacterial cell division process. It is widely conserved and expressed in both Gram-positive and Gram-negative strains. In the last decade, several research groups have pointed out molecules able to targ...

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Bibliographic Details
Main Authors: Valentina Straniero, Lorenzo Suigo, Andrea Casiraghi, Victor Sebastián-Pérez, Martina Hrast, Carlo Zanotto, Irena Zdovc, Carlo De Giuli Morghen, Antonia Radaelli, Ermanno Valoti
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Antibiotics
Subjects:
cell division protein FtsZ
benzamide
1,4-benzodioxane
1,4-benzoxathiane
multi-drug resistant <i>Staphylococcus aureus</i>
<i>Escherichia coli</i> N43
Online Access:https://www.mdpi.com/2079-6382/9/4/160

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https://www.mdpi.com/2079-6382/9/4/160

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