Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants

Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants

BackgroundChronic hepatitis B virus (HBV) infection is the leading cause of hepatocellular carcinoma (HCC) world-wide. HBV variants, particularly the G1896A pre-core (PC) and A1762T/G1764A basal core promoter (BCP) mutations, are established risk factors for cirrhosis and HCC, but the molecular biol...

Full description

Bibliographic Details
Main Authors: Keith C. K. Lau, Shivali S. Joshi, Douglas J. Mahoney, Andrew L. Mason, Guido van Marle, Carla Osiowy, Carla S. Coffin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Microbiology
Subjects:
viral hepatitis
genetic variants
APOBEC3 family
in vitro characterization
HBV precore/basal core promoter mutations
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01653/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01653/full

Similar Items