Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

Abstract Background Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease with fast progression. ALS has heavy genetic components in which a series of genetic mutations have been identified. In 2013, Mutations of the CREST gene (also known as SS18L1), which functions as a cal...

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Bibliographic Details
Main Authors: Cheng Cheng, Kan Yang, Xinwei Wu, Yuefang Zhang, Shifang Shan, Aaron Gitler, Anirvan Ghosh, Zilong Qiu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Translational Neurodegeneration
Subjects:
ALS
CREST
Neuroinflammation
Cytokine
Microglia
Online Access:http://link.springer.com/article/10.1186/s40035-019-0152-1

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http://link.springer.com/article/10.1186/s40035-019-0152-1

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